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Psychedelic drug Wikipedia Soyka et al. used FDG PET in 10 unmedicated schizophrenia patients with vivid positive symptoms. Schizophrenia patients had higher, but nonsignificant, regional metabolic rates of glucose in almost all quantified regions compared with controls, but the right/left frontal-occipital metabolic ratio was significantly higher for the schizophrenia patients, indicating a hypermetabolic pattern. There are no clinical studies of the effect of psychedelics on memory or cognitive function, but there is a reasonable basis to believe they might have a beneficial effect on memory or cognitive deficits, at least acutely. It is known that 5-HT2A receptors have a role in cognitive function of working memory that involves actions at both excitatory and inhibitory elements within local circuitry (Williams et al., 2002). R-DOI was also able to block dose-dependently and completely TNF-α–induced levels of circulating IL-6 in the blood. Importantly, antagonist studies using t